Chemical Exchange Saturation Transfer (CEST) Agents: Quantum Chemistry and MRI
نویسندگان
چکیده
منابع مشابه
Responsive paramagnetic chemical exchange saturation transfer MRI contrast agents
Molecular imaging research has shown great potential to assess the molecular compositions of tissues and provide critical information for clinical diagnoses [1]. These noninvasive assessments of molecular compositions may provide earlier diagnoses of pathologies, may predict therapeutic effects before the therapy is initiated and may provide earlier assessments of therapeutic effects soon after...
متن کاملSimplified and scalable numerical solution for describing multi-pool chemical exchange saturation transfer (CEST) MRI contrast.
Chemical exchange saturation transfer (CEST) imaging is sensitive to dilute labile proton and microenvironment properties such as pH and temperature, and provides vital information complementary to the conventional MRI methods. Whereas the Bloch equations coupled by exchange terms (i.e., Bloch-McConnell equations) have been utilized to quantify 2-pool CEST contrast, it is tedious to extend the ...
متن کاملMolecular imaging of tumors and metastases using chemical exchange saturation transfer (CEST) MRI.
The two glucose analogs 2-deoxy-D-glucose (2-DG) and 2-fluoro-2-deoxy-D-glucose (FDG) are preferentially taken up by cancer cells, undergo phosphorylation and accumulate in the cells. Owing to their exchangeable protons on their hydroxyl residues they exhibit significant chemical exchange saturation transfer (CEST) effect in MRI. Here we report CEST-MRI on mice bearing orthotopic mammary tumors...
متن کاملAn Improved Empirical Solution for Describing Chemical Exchange Saturation Transfer (CEST) MRI
Introduction Both numerical simulation and analytical solution have been developed to describe CEST MRI phenomenon, which have aided our ability to quantify and optimize CEST imaging 1,2. In fact, a concise empirical solution has been proposed which decomposes CEST contrast as a product of the “ideal” contrast, saturation coefficient and spillover factor 3. However, the empirical solution is on...
متن کاملNoninvasive MRI of tissue redox state based on endogenous chemical exchange saturation transfer (CEST) contrast
Target audience: Research scientists or clinicians who are interested in cancer metabolism, oxidative stress and redox state. Introduction/Purpose: Cellular redox state has been demonstrated as a key player in cellular biology. The disturbed balance of the redox state, such as excessive oxidative stress, can lead to many pathologic changes including cancer, heart diseases, neurodegenerative dis...
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ژورنال
عنوان ژورنال: Chemistry - A European Journal
سال: 2015
ISSN: 0947-6539
DOI: 10.1002/chem.201503942